Predicting drug-drug interactions from in vitro drug metabolism data: challenges and recent advances.

@article{Obach2009PredictingDI,
  title={Predicting drug-drug interactions from in vitro drug metabolism data: challenges and recent advances.},
  author={R Scott Obach},
  journal={Current opinion in drug discovery & development},
  year={2009},
  volume={12 1},
  pages={81-9}
}
  • R Scott Obach
  • Published 2009 in Current opinion in drug discovery & development
Drug-drug interactions (DDI) caused by the inhibition, inactivation or induction of cytochrome P450 enzymes have been an area of intense research. Models to predict DDI from in vitro data have proven useful and accurate. However, some uncertainty remains over several specific parameters used in these models, such as which value best represents the in vivo concentration of the inhibitor/ inactivator/inducer ([I](in vivo)); the rate of degradation of P450 enzymes in vivo (k(deg)); the fraction of… CONTINUE READING

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