Predicting disease recurrence in patients with previous unprovoked venous thromboembolism: a proposed prediction score (DASH)

@article{Tosetto2012PredictingDR,
  title={Predicting disease recurrence in patients with previous unprovoked venous thromboembolism: a proposed prediction score (DASH)},
  author={Alberto Tosetto and Alfonso Iorio and Maura Marcucci and Trevor P Baglin and Mary Cushman and Sabine Eichinger and Gualtiero Palareti and Daniela Poli and R Campbell Tait and James D Douketis},
  journal={Journal of Thrombosis and Haemostasis},
  year={2012},
  volume={10}
}
Summary.  Background:  In patients with unprovoked venous thromboembolism (VTE), the optimal duration of anticoagulation is anchored on estimating the risk of disease recurrence. 
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371 Citations

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Understanding venous thromboembolism recurrence risk is central to determining the appropriate treatment course and whether this risk varies after discontinuing anticoagulation or overall by type of incident event and by the detailed location of the DVT needs further clarification.
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Patients with venous thromboembolism (VTE) secondary to transient risk factors may develop VTE recurrences after discontinuing anticoagulation. Identifying at‐risk patients could help to guide the…
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TLDR
A maturing approach to acute and long-term management of venous thromboembolism is focused on personalizing therapy.
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TLDR
This study assessed predictors of pulmonary thromboembolism (PE) resolution and their implications for clinical outcome and found no clear relationships between these predictors and clinical outcome.
D‐dimer at venous thrombosis diagnosis is associated with risk of recurrence
TLDR
A low D‐dimer at first VTE diagnosis was associated with a low recurrence risk, and the association was predominant in patients with deep vein thrombosis and unprovoked VTE.
Venous thromboembolism: risk of recurrence and long-term anticoagulation.
Recurrence following initial treatment for venous thromboembolism is a significant cause of morbidity and mortality. Balancing the risks of recurrence against the risks of long-term anticoagulation…
Prevention and treatment of venous thromboembolic disease
TLDR
The risk factors for venous thromboembolic disease and the recommended strategies to prevent VTE are examined, as well as discussing the diagnosis and treatment of an event that has already occurred.
Provoked versus unprovoked venous thromboembolism: Findings from GARFIELD‐VTE
Venous thromboembolism (VTE) has a long‐term risk of recurrence, dependent on the presence or absence of provoking risk factors at the time of the event.
Predictive value of factor VIII levels for recurrent venous thrombosis: results from the MEGA follow‐up study
TLDR
Prediction of recurrent venous thrombosis remains a challenge in the clinic and the use of EMT is still a challenge.
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References

SHOWING 1-10 OF 35 REFERENCES
Risk Assessment of Recurrence in Patients With Unprovoked Deep Vein Thrombosis or Pulmonary Embolism: The Vienna Prediction Model
TLDR
By use of a simple scoring system, the assessment of the recurrence risk in patients with a first unprovoked VTE and without strong thrombophilic defects can be improved.
Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy
TLDR
Women with 0 or 1 risk factor may safely discontinue oral anticoagulant therapy after 6 months of therapy following a first unprovoked venous thromboembolism, and this criterion does not apply to men.
Systematic Review: d-Dimer to Predict Recurrent Disease after Stopping Anticoagulant Therapy for Unprovoked Venous Thromboembolism
TLDR
A systematic review and meta-analysis of studies that measured d-dimer in patients who had stopped anticoagulant therapy for a first episode of unprovoked VTE to assess the value of d-Dimer as a predictor of recurrent disease provided precise and reliable estimates of the risk for recurrent VTE.
The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients.
TLDR
Besides unprovoked presentation, other factors independently associated with a statistically significant increased risk of recurrent VTE are thrombophilia, clinical presentation with primary DVT, shorter duration of anticoagulation, and increasing age.
D-dimer levels and risk of recurrent venous thromboembolism.
TLDR
Patients with a first spontaneous VTE and a D-dimer level of less than 250 ng/mL after withdrawal of oral anticoagulation have a low risk of VTE recurrence, and a laboratory method that measures multifactorial thrombophilia is required.
Patient outcomes after deep vein thrombosis and pulmonary embolism: the Worcester Venous Thromboembolism Study.
TLDR
Clinical characteristics and outcomes of patients with validated symptomatic PE and isolated DVT in a New England community are measured to identify patients most at risk for VTE-associated complications and to develop better anticoagulation strategies conducive to long-term use in the community setting.
Predictive Value of D‐Dimer Test for Recurrent Venous Thromboembolism After Anticoagulation Withdrawal in Subjects With a Previous Idiopathic Event and in Carriers of Congenital Thrombophilia
TLDR
D‐dimer levels measured 1 month after OAT withdrawal have a high negative predictive value for recurrence in subjects with unprovoked VTE who are either carriers or not carriers of congenital thrombophilia.
D-dimer testing to determine the duration of anticoagulation therapy.
TLDR
Patients with an abnormal D-dimer level 1 month after the discontinuation of anticoagulation have a significant incidence of recurrent venous thromboembolism, which is reduced by the resumption of antICOagulation.
Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT)
Residual thrombosis on ultrasonography to guide the duration of anticoagulation in patients with deep venous thrombosis: a randomized trial.
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