Predicting coma and other low responsive patients outcome using event-related brain potentials: A meta-analysis

  title={Predicting coma and other low responsive patients outcome using event-related brain potentials: A meta-analysis},
  author={J{\'e}r{\^o}me Daltrozzo and Norma Wioland and V{\'e}ronique Mutschler and Boris Kotchoubey},
  journal={Clinical Neurophysiology},

A tree of life? Multivariate logistic outcome-prediction in disorders of consciousness

Individual outcome chances for patients with DOC are specified on the basis of clinical and event-related-potentials (ERPs) data and subgroups, who vary substantially regarding their outcome chances are identified.

The Combination of N60 with Mismatch Negativity Improves the Prediction of Awakening from Coma

The combination of the N60 and MMN improved the prediction of an awakening outcome in patients who were comatose at 7 days after coma onset, and the use of event-related potentials and the middle-latency somatosensory evoked potential best predict an awakening outcomes.

Cognitive Event-Related Potentials during the Sub-Acute Phase of Severe Traumatic Brain Injury and Their Relationship to Outcome.

Electroencephalography-based event-related potentials can index cognitive capacities in the early phase following sTBI, and the cognitive P3 component in an active design is associated with functional and cognitive outcome, demonstrating that the Cognitive P3 may yield valuable information of residual cognition and provide supplementary prognostic information.

Multicenter prospective study on predictors of short-term outcome in disorders of consciousness

Young age, shorter time postinjury, higher Coma Recovery Scale–Revised total score, and presence of EEG reactivity to eye opening at study entry predicted better outcome, whereas etiology, clinical diagnosis, Disability Rating Scale score, EEG background activity, acoustic reactivity, and P300 on event-related potentials were not associated with outcome.

Predictive value of EEG-awakening for behavioral awakening from coma

EEG-awakening incorporates both EEG-R and sleep spindles and is an excellent predictor for early behavioral awakening in comatose patients and shows an outstanding discriminative power for awakening.

Assessing consciousness with auditory event-related potential during coma recovery: a case study

MMN and P300 may occur earlier than believed in patients in persistent VS and MCS; their predictive values for prognosis need to be further confirmed by follow-up studies on a large clinical sample.

Two-dimensional maps to predict the neurological recovery after cardiac arrest

A method to predict the return to consciousness and good neurological outcome based on the analysis of responses to auditory periodic stimulations to auditory evoked potentials, which could provide an alternative tool to intensivists to better evaluate neurological outcome and improve patient management, without neurophysiologist assistance.

Auditory P300 and mismatch negativity in comatose states




Predictive value of sensory and cognitive evoked potentials for awakening from coma

The presence of MMN is a predictor of awakening and precludes comatose patients from moving to a permanent vegetative state, and Evaluation of primary sensory cortex and higher-order processes by middle-latency-, late, and cognitive evoked potentials should be performed in the prognosis for awakening in com atose patients.

Event-related potentials — neurophysiological tools for predicting emergence and early outcome from traumatic coma

Highly significant correlations exist between long-latency ERP components and 3-month outcome, and pupillary response patterns, APACHE II and Glasgow Coma Scores correlate significantly with outcome, as do the retrospective measures of duration of coma and post-traumatic amnesia in survivors.

Coma Outcome Prediction Using Event-Related Potentials: P3 and Mismatch Negativity

The presence of long-latency event-related potentials has been shown to be a useful predictor of a favourable neurological outcome, and thus their use complements other neurophysiological techniques.

Improved prediction of awakening or nonawakening from severe anoxic coma using tree-based classification analysis*

A prognostic tree for the prediction of awakening/nonawakening in severe anoxic coma has been designed and offers the possibility to predict with very high probability awakening when MMN, the earliest component of event-related potentials, is present and nonawakening whenMMN and pupillary light reflex are absent or cortical components of somatosensory evoked potentials are abolished.

Use of Somatosensory-Evoked Potentials and Cognitive Event-Related Potentials in Predicting Outcomes of Patients with Severe Traumatic Brain Injury

Although median nerve SEP continues to make reliable prediction of ominous outcome in severe traumatic brain injury, the addition of the speech-evoked ERPs may be helpful in predicting favorable outcomes.

Predictive value of P300 event‐related potentials compared with EEG and somatosensory evoked potentials in non‐traumatic coma

It is concluded that, in addition to EEG and SEP, the P300 should be considered in the prognostic evaluation of patients in nontraumatic coma and simplified scales for the EEG andSEP are predictive of depth of coma and outcome.

Magnetization transfer imaging and proton MR spectroscopy in the evaluation of axonal injury: correlation with clinical outcome after traumatic brain injury.

MTR and MR spectroscopy can quantify damage after TBI, and NAA levels may be a sensitive indicator of the neuronal damage that results in a worse clinical outcome.

Topographic Brain Mapping of EEG and Evoked Potentials

  • K. Maurer
  • Biology
    Springer Berlin Heidelberg
  • 1989
The aim of this book is to clarify the current state of this emerging technology, to assess its potential for substantive contributions to brain research, to delineate areas for further research and, over all, to envisage clinical applications in disciplines such as psychiatry, neurology, and neuropsychology.