Predicting cognitive decline in Alzheimer's disease: an integrated analysis.

  title={Predicting cognitive decline in Alzheimer's disease: an integrated analysis.},
  author={Oscar L. Lopez and Elias M Schwam and Jeffrey Cummings and Serge Gauthier and R. W. A. Jones and David Wilkinson and Gunhild Waldemar and Richard W Zhang and Rachel J. Schindler},
  journal={Alzheimer's & dementia : the journal of the Alzheimer's Association},
  volume={6 6},
BACKGROUND Numerous patient- and disease-related factors increase the risk of rapid cognitive decline in patients with Alzheimer's disease (AD). The ability of pharmacological treatment to attenuate this risk remains undefined. METHODS Pooled data from 14 randomized clinical studies of donepezil in the treatment of AD (N = 3748) were analyzed to identify predictors of fast decline and determine the effect of donepezil on the risk of fast decline. RESULTS Young age and more severe baseline… CONTINUE READING

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