Predicting clone genotypes from tumor bulk sequencing of multiple samples

@article{Miura2018PredictingCG,
  title={Predicting clone genotypes from tumor bulk sequencing of multiple samples},
  author={Sayaka Miura and Karen Gomez and Oscar Murillo and Louise A. Huuki and Trung Vu and Tiffany Buturla and Sudhir Kumar},
  journal={Bioinformatics},
  year={2018},
  volume={34 23},
  pages={
          4017-4026
        }
}
Motivation Analyses of data generated from bulk sequencing of tumors have revealed extensive genomic heterogeneity within patients. Many computational methods have been developed to enable the inference of genotypes of tumor cell populations (clones) from bulk sequencing data. However, the relative and absolute accuracy of available computational methods in estimating clone counts and clone genotypes is not yet known. Results We have assessed the performance of nine methods, including eight… CONTINUE READING
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