Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.

@article{Parvatiyar2010PredictingCP,
  title={Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.},
  author={Michelle S. Parvatiyar and Jose R Pinto and Jingsheng Liang and James D. Potter},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 36},
  pages={27785-97}
}
Cardiac diseases associated with mutations in troponin subunits include hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy (RCM). Altered calcium handling in these diseases is evidenced by changes in the Ca(2+) sensitivity of contraction. Mutations in the Ca(2+) sensor, troponin C (TnC), were generated to increase/decrease the Ca(2+) sensitivity of cardiac skinned fibers to create the characteristic effects of DCM, HCM, and RCM. We also used a… CONTINUE READING