Predicting active site residue annotations in the Pfam database

@article{Mistry2007PredictingAS,
  title={Predicting active site residue annotations in the Pfam database},
  author={Jaina Mistry and Alex Bateman and Robert D. Finn},
  journal={BMC Bioinformatics},
  year={2007},
  volume={8},
  pages={298 - 298}
}
Approximately 5% of Pfam families are enzymatic, but only a small fraction of the sequences within these families (<0.5%) have had the residues responsible for catalysis determined. To increase the active site annotations in the Pfam database, we have developed a strict set of rules, chosen to reduce the rate of false positives, which enable the transfer of experimentally determined active site residue data to other sequences within the same Pfam family. We have created a large database of… CONTINUE READING
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