Predicting Radiosensitivity with Gamma-H2AX Foci Assay after Single High-Dose-Rate and Pulsed Dose-Rate Ionizing Irradiation.

Abstract

Gamma-H2AX foci detection is the standard method to quantify DNA double-strand break (DSB) induction and repair. In this study, we investigated the induction and decay of γ-H2AX foci of different tumor cell lines and fibroblasts with known mutations in DNA damage repair genes, including ATM, LigIV, DNA-PKcs, Rad51 and Rad54. A radiation dose of 2.4 Gy was… (More)
DOI: 10.1667/RR14098.1

Topics

Cite this paper

@article{Oorschot2016PredictingRW, title={Predicting Radiosensitivity with Gamma-H2AX Foci Assay after Single High-Dose-Rate and Pulsed Dose-Rate Ionizing Irradiation.}, author={Bregje van Oorschot and Suzanne E Hovingh and Annelot M Dekker and Lukas J. A. Stalpers and Nicolaas A P Franken}, journal={Radiation research}, year={2016}, volume={185 2}, pages={190-8} }