Predicting Pharmacodynamic Drug-Drug Interactions through Signaling Propagation Interference on Protein-Protein Interaction Networks

@inproceedings{Park2015PredictingPD,
  title={Predicting Pharmacodynamic Drug-Drug Interactions through Signaling Propagation Interference on Protein-Protein Interaction Networks},
  author={Kyunghyun Park and Docyong Kim and Suhyun Ha and Doheon Lee and Miguel {\'A}ngel Medina},
  booktitle={PloS one},
  year={2015}
}
As pharmacodynamic drug-drug interactions (PD DDIs) could lead to severe adverse effects in patients, it is important to identify potential PD DDIs in drug development. The signaling starting from drug targets is propagated through protein-protein interaction (PPI) networks. PD DDIs could occur by close interference on the same targets or within the same pathways as well as distant interference through cross-talking pathways. However, most of the previous approaches have considered only close… CONTINUE READING
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