Predicting Oral Absorption of Drugs: A Case Study with a Novel Class of Antimicrobial Agents

@article{Hilgers2003PredictingOA,
  title={Predicting Oral Absorption of Drugs: A Case Study with a Novel Class of Antimicrobial Agents},
  author={Allen R. Hilgers and Donald P. Smith and John J. Biermacher and Jeffrey S. Day and Jana L. Jensen and Sandra M. Sims and Wade J. Adams and Janice M. Friis and Joe Palandra and J D Hosley and E M Shobe and Philip S. Burton},
  journal={Pharmaceutical Research},
  year={2003},
  volume={20},
  pages={1149-1155}
}
AbstractPurpose. The purpose of this work was to evaluate an oral absorption prediction model, maximum absorbable dose (MAD), which predicts a theoretical dose of drug that could be absorbed across rat intestine based on consideration of intestinal permeability, solute solubility, intestinal volume, and residence time. Methods. In the present study, Caco-2 cell permeability, as a surrogate for rat intestinal permeability, and aqueous solubility were measured for 27 oxazolidinones. The… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Predicting drug absorption: how nature made it a difficult problem.

  • The Journal of pharmacology and experimental therapeutics
  • 2002
VIEW 4 EXCERPTS
CITES BACKGROUND

Physiologically based pharmacokinetic modeling for assessing the clinical drug-drug interaction of alisporivir.

  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2014
VIEW 4 EXCERPTS
CITES METHODS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 23 REFERENCES

Rapid assessment of drug metabolism in the drug discovery process.

  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2000

acceptable pharmacokinetic properties utilizing combined physicochemical, in vitro and in vivo screens

G. W. Caldwell. Compound optimization in early-, late-phase drug discovery
  • Curr. Opin. Drug Dis. Develop. 3:30–41
  • 2000
VIEW 1 EXCERPT

Characterization of the Caco-2 permeability model and rat intestinal perfusion model for use With the Biopharmaceutics Classification System

J. S. Bourdage, P. S. Burton, +4 authors W. P. Pfund
  • AAPS PharmSci
  • 1999
VIEW 1 EXCERPT