Predicting Multidrug-Resistant Gram-Negative Bacterial Colonization and Associated Infection on Hospital Admission

  title={Predicting Multidrug-Resistant Gram-Negative Bacterial Colonization and Associated Infection on Hospital Admission},
  author={Wen-Pin Tseng and Yee-Chun Chen and Bey-Jing Yang and Shang-Yu Chen and Jr-Jiun Lin and Ya‐Huei Huang and Chia-Ming Fu and Shan-Chwen Chang and Shey-Ying Chen},
  journal={Infection Control \&\#x0026; Hospital Epidemiology},
  pages={1216 - 1225}
OBJECTIVE Isolation of multidrug-resistant gram-negative bacteria (MDR-GNB) from patients in the community has been increasingly observed. A prediction model for MDR-GNB colonization and infection risk stratification on hospital admission is needed to improve patient care. METHODS A 2-stage, prospective study was performed with 995 and 998 emergency department patients enrolled, respectively. MDR-GNB colonization was defined as isolates resistant to 3 or more classes of antibiotics, identified… 

Risk for subsequent infection and mortality after hospitalization among patients with multidrug-resistant gram-negative bacteria colonization or infection

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Risk stratification for multidrug-resistant Gram-negative infections in ICU patients.

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Active Surveillance Cultures and Procalcitonin in Combination With Clinical Data to Guide Empirical Antimicrobial Therapy in Hospitalized Medical Patients With Sepsis

This study is the first to show that the positivity of surveillance swabs, in combination with anamnestic data, PCT values, and SIRS or q-SOFA scores, serves as a valuable tool to help clinicians predict patients at higher risk for swab-related infection development and guide the administration of appropriate empiric antimicrobial therapy in septic patients.

Novel Approaches to Hasten Detection of Pathogens and Antimicrobial Resistance in the Intensive Care Unit.

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Predicting Multidrug-Resistant Gram-Negative Bacterial Colonization and Associated Infection on Hospital Admission: Methodological Issues

Factors and genetic characteristics of methicillin-resistant and -susceptible Staphylococcus aureus isolates in Myanmar and a new type of MRSA are studied.

Derivation and Validation of a Predictive Scoring Model of Infections Due to Acinetobacter baumannii in Patients with Hospital Acquired Pneumonia by Gram-Negative Bacilli

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Association between Timing of Colonization and Risk of Developing Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae Infection in Hospitalized Patients

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The rising influx of multidrug-resistant gram-negative bacilli into a tertiary care hospital.

  • A. Pop-VicasE. D’Agata
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2005
Identification of common coresistance patterns among MDR-GNB isolates may assist in the selection of empirical antimicrobial therapy for patients with a high risk of harboring MDR -GNB at hospital admission.

The Increasing Challenge of Multidrug-Resistant Gram-Negative Bacilli

This study confirms that MDR GNB are an increasing challenge to NICUs and can be an important tool to optimize antimicrobials use and control the emergence and dissemination of resistances in NICU.

Prediction models to identify hospitalized patients at risk of being colonized or infected with multidrug-resistant Acinetobacter baumannii calcoaceticus complex.

The highest predicting value was observed for the presence of more than two risk factors and colonization in patients with no history of ICU admission, indicating novel information can be used to identify interventions for different stages of the spread of MDR-Abc.

A prediction tool for nosocomial multi-drug resistant gram-negative bacilli infections in critically ill patients - prospective observational study

GSDCS is a simple bedside clinical score which predicts RGNB infection and bacteremia with high predictive value and differentiates low versus high risk patients and will help clinicians to choose appropriate, timely targeted antibiotic therapy.

Colonization with multidrug-resistant gram-negative bacteria: prolonged duration and frequent cocolonization.

Patient colonization with MDRGNB is prolonged, and a substantial proportion of patients are colonized with multiple MDR GNB species, and multidrug-resistant P. mirabilis may have a survival advantage in the gastrointestinal tract, compared with other MDRGH species.

Clinical predictive values of extended-spectrum beta-lactamase carriage in patients admitted to medical wards

The clinical prediction of ESBL carriage at admission in wards was found to be poorly efficient for assessing the at-risk population and to assess the risk of further positive clinical culture of ESBM among carriers.

Predicting carriage with extended-spectrum beta-lactamase-producing bacteria at hospital admission: a cross-sectional study.

Community-acquired bloodstream infection in critically ill adult patients: impact of shock and inappropriate antibiotic therapy on survival.

Inappropriate antimicrobial treatment is the most important influence on outcome in patients admitted to the ICU for community-acquired BSI, particularly in presence of septic shock or high degrees of severity.