Predicting Heparin Responsiveness in Children Before Cardiopulmonary Bypass: A Retrospective Cohort Study.

@article{Nakamura2018PredictingHR,
  title={Predicting Heparin Responsiveness in Children Before Cardiopulmonary Bypass: A Retrospective Cohort Study.},
  author={Sayaka Nakamura and Osami Honjo and Lynn Crawford-Lean and Celeste Foreman and Minako Sano and James D. O'Leary},
  journal={Anesthesia and analgesia},
  year={2018},
  volume={126 5},
  pages={1617-1623}
}
BACKGROUND Inadequate or excess administration of unfractionated heparin for cardiopulmonary bypass (CPB) can cause significant harm. Age-dependent differences in the pharmacodynamics and pharmacokinetics of heparin contribute to increased variability of heparin responsiveness in children. The aims of the current study were to (1) examine the correlation between predicted and observed heparin responsiveness in children before CPB measured using the Hemostasis Management System (HMS) Plus… CONTINUE READING
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