Predicting HLA class II alloantigen immunogenicity from the number and physiochemical properties of amino acid polymorphisms.

@article{Kosmoliaptsis2011PredictingHC,
  title={Predicting HLA class II alloantigen immunogenicity from the number and physiochemical properties of amino acid polymorphisms.},
  author={Vasilis Kosmoliaptsis and Linda D. Sharples and Afzal N. Chaudhry and David John Halsall and J Andrew Bradley and Craig J. Taylor},
  journal={Transplantation},
  year={2011},
  volume={91 2},
  pages={183-90}
}
BACKGROUND We have shown previously that human leukocyte antigen (HLA) class I immunogenicity can be predicted by the number, position, and physiochemical differences of polymorphic amino acids (AAs). We have now modeled the structural and physiochemical polymorphisms of HLA class II alloantigens and correlated these with humoral alloimmunity in sensitized patients awaiting kidney transplantation. METHODS Sera obtained from 30 patients with high levels of IgG HLA-specific antibodies were… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Alloantibody Responses After Renal Transplant Failure Can Be Better Predicted by Donor–Recipient HLA Amino Acid Sequence and Physicochemical Disparities Than Conventional HLA Matching

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons • 2016
View 1 Excerpt

Hiding in Plain Sight-A New Look at HLA Epitopes: A Case Report.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons • 2016

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Reducing de novo donor-specific antibody levels during acute rejection diminishes renal allograft loss.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons • 2009

Similar Papers

Loading similar papers…