Predicting HIV drug resistance with neural networks

  title={Predicting HIV drug resistance with neural networks},
  author={Sorin Draghici and R. Brian Potter},
  volume={19 1},
MOTIVATION Drug resistance is a very important factor influencing the failure of current HIV therapies. The ability to predict the drug resistance of HIV protease mutants may be useful in developing more effective and longer lasting treatment regimens. METHODS The HIV resistance is predicted to two current protease inhibitors, Indinavir and Saquinavir. The problem was approached from two perspectives. First, a predictor was constructed based on the structural features of the HIV protease-drug… CONTINUE READING
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