Predicting Functional Alternative Splicing by Measuring RNA Selection Pressure from Multigenome Alignments

@inproceedings{Lu2009PredictingFA,
  title={Predicting Functional Alternative Splicing by Measuring RNA Selection Pressure from Multigenome Alignments},
  author={Hongchao Lu and Lan Lin and Seiko Sato and Yi Xing and Christopher J. Lee},
  booktitle={PLoS Computational Biology},
  year={2009}
}
High-throughput methods such as EST sequencing, microarrays and deep sequencing have identified large numbers of alternative splicing (AS) events, but studies have shown that only a subset of these may be functional. Here we report a sensitive bioinformatics approach that identifies exons with evidence of a strong RNA selection pressure ratio (RSPR)--i.e., evolutionary selection against mutations that change only the mRNA sequence while leaving the protein sequence unchanged--measured across an… CONTINUE READING

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