Predicted structure of the extracellular region of ligand-gated ion-channel receptors shows SH2-like and SH3-like domains forming the ligand-binding site.

@article{Gready1997PredictedSO,
  title={Predicted structure of the extracellular region of ligand-gated ion-channel receptors shows SH2-like and SH3-like domains forming the ligand-binding site.},
  author={Jill E. Gready and Senthil Ranganathan and Peter R. Schofield and Y. Matsuo and Ken Nishikawa},
  journal={Protein science : a publication of the Protein Society},
  year={1997},
  volume={6 5},
  pages={983-98}
}
Fast synaptic neurotransmission is mediated by ligand-gated ion-channel (LGIC) receptors, which include receptors for acetylcholine, serotonin, GABA, glycine, and glutamate. LGICs are pentamers with extracellular ligand-binding domains and form integral membrane ion channels that are selective for cations (acetylcholine and serotonin 5HT3 receptors) or… CONTINUE READING