Predicted structural basis for CD1c presentation of mycobacterial branched polyketides and long lipopeptide antigens.

CD1 proteins mediate the trafficking and presentation of a diverse range of lipid antigens to T-cell receptors, and thus play a key role in our adaptive immune system. Crystal structures of several CD1 isoforms reveal a highly conserved tertiary structure, but also great variability in the anatomy of their binding pockets, reflecting their distinct ligand… CONTINUE READING