Predicted expansion of the claudin multigene family.

  title={Predicted expansion of the claudin multigene family.},
  author={Katsuhiko Mineta and Yasuko Yamamoto and Yuji Yamazaki and Hiroo Tanaka and Yukiyo Tada and Kuniaki Saito and Atsushi Tamura and Michihiro Igarashi and Toshinori Endo and Kosei Takeuchi and Sachiko Tsukita},
  journal={FEBS letters},
  volume={585 4},
Claudins (Cldn) are essential membrane proteins of tight junctions (TJs), which form the paracellular permselective barrier. They are produced by a multi-gene family of 24 reported members in mouse and human. Based on a comprehensive search combined with phylogenetic analyses, we identified three novel claudins (claudin-25, -26, and -27). Quantitative RT-PCR revealed that the three novel claudins were expressed in a tissue- and/or developmental stage-dependent manner. Claudins-25 and -26, but… CONTINUE READING
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Molecular basis for cation selectivity in claudin-2-based pores

  • A. Yu
  • Ann. N.Y. Acad. Sci
  • 2009
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