Predicted 25(OH)D score and colorectal cancer risk according to vitamin D receptor expression.

@article{Jung2014Predicted2S,
  title={Predicted 25(OH)D score and colorectal cancer risk according to vitamin D receptor expression.},
  author={Seungyoun Jung and Zhi Rong Qian and Mai Yamauchi and Kimberly A Bertrand and Kathryn C. Fitzgerald and Yuichi Ishikawa and Sun A Kim and Kosuke Mima and Yasutaka Sukawa and Xuehong Zhang and Molin Wang and Stephanie A. Smith-Warner and Kana Wu and Charles S. Fuchs and Andrew T. Chan and Edward L. Giovannucci and Kimmie Ng and Eunyoung Cho and Shuji Ogino and Reiko Nishihara},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2014},
  volume={23 8},
  pages={
          1628-37
        }
}
BACKGROUND Despite accumulating evidence for the preventive effect of vitamin D on colorectal carcinogenesis, its precise mechanisms remain unclear. We hypothesized that vitamin D was associated with a lower risk of colorectal cancer with high-level vitamin D receptor (VDR) expression, but not with risk of tumor with low-level VDR expression. METHODS Among 140,418 participants followed from 1986 through 2008 in the Nurses' Health Study and the Health Professionals' Follow-up Study, we… CONTINUE READING
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