Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology.

@article{Hemmer1998PredictableTA,
  title={Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology.},
  author={Bernhard Hemmer and Marco Vergelli and Bruno Gran and Nicholas Ling and Paul A. Conlon and Clemencia Pinilla and Richard Houghten and Henry F. McFarland and Roland Martin},
  journal={Journal of immunology},
  year={1998},
  volume={160 8},
  pages={3631-6}
}
The potential of CD4+ T cells for cross-recognition of self and foreign Ags has important implications for the understanding of thymic selection, lymphocyte survival, and the occurrence of autoimmune diseases. Here, we define the extensive flexibility of Ag recognition for three human CD4+ autoreactive T cell clones (TCC) by using ligands with single and multiple amino acid (aa) substitutions. Our results demonstrate that the spectrum of tolerated ligands and the resulting stimulatory potency… CONTINUE READING

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