Prediagnostic levels of C-peptide, IGF-I, IGFBP -1, -2 and -3 and risk of endometrial cancer†

  title={Prediagnostic levels of C-peptide, IGF-I, IGFBP -1, -2 and -3 and risk of endometrial cancer†},
  author={Annekatrin Lukanova and Anne Zeleniuch-Jacquotte and Eva A Lundin and Andrea Micheli and Alan A. Arslan and Sabina Rinaldi and Paola C. Muti and Per Lenner and Karen L. Koenig and Carine Biessy and Vittorio Krogh and Elio Riboli and Roy E. Shore and P{\aa}r Stattin and Franco Berrino and G{\"o}ran Hallmans and Paolo G. Toniolo and Rudolf Kaaks},
  journal={International journal of cancer},
  volume={108 2},
Conditions related to chronic hyperinsulinemia, such as obesity, noninsulin dependent diabetes mellitus and polycystic ovary syndrome, are associated with an increased risk of endometrial cancer. Elevated plasma IGF-I and decreased levels of IGF-binding proteins have been shown to be associated with increased risk of several cancer types that are frequent in affluent societies. We investigated for the first time in a prospective study the association of pre-diagnostic blood concentrations of C… CONTINUE READING


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