Prediagnostic body size and risk of amyotrophic lateral sclerosis death in 10 studies.

@article{Oreilly2018PrediagnosticBS,
  title={Prediagnostic body size and risk of amyotrophic lateral sclerosis death in 10 studies.},
  author={Eilis J O'reilly and Molin Wang and Hans-Olov Adami and Alvaro Alonso and Leslie Bernstein and Piet A van den Brandt and Julie E. Buring and Sarah E. Daugherty and Dennis M. Deapen and Daryl Michal Freedman and Dallas English and Graham G. Giles and Niclas H{\aa}kansson and Tobias Kurth and Catherine Schairer and Elisabete Weiderpass and Alicja Wolk and Stephanie A. Smith-Warner},
  journal={Amyotrophic lateral sclerosis & frontotemporal degeneration},
  year={2018},
  volume={19 5-6},
  pages={
          396-406
        }
}
OBJECTIVES AND METHODS Using pooled multivariable-adjusted rate ratios (RR), we explored relationships between prediagnostic body-mass-index (BMI), waist-to-hip-ratio (WHR), and weight-gain during adulthood, and ALS in 419,894 women and 148,166 men from 10 community-based cohorts in USA, Europe, and Australia; 428 ALS deaths were documented in women and 204 in men. RESULTS Higher mid-to-later adulthood BMI was associated with lower ALS mortality. For 5 kg/m2 increased BMI, the rate was 15… CONTINUE READING
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