Predator stress engages corticotropin-releasing factor and opioid systems to alter the operating mode of locus coeruleus norepinephrine neurons

@article{Curtis2012PredatorSE,
  title={Predator stress engages corticotropin-releasing factor and opioid systems to alter the operating mode of locus coeruleus norepinephrine neurons},
  author={Andre L. Curtis and Steven C. Leiser and Kevin A. Snyder and Rita J Valentino},
  journal={Neuropharmacology},
  year={2012},
  volume={62},
  pages={1737-1745}
}
The norepinephrine nucleus, locus coeruleus (LC), has been implicated in cognitive aspects of the stress response, in part through its regulation by the stress-related neuropeptide, corticotropin-releasing factor (CRF). LC neurons discharge in tonic and phasic modes that differentially modulate attention and behavior. Here, the effects of exposure to an ethologically relevant stressor, predator odor, on spontaneous (tonic) and auditory-evoked (phasic) LC discharge were characterized in… CONTINUE READING

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