• Biology, Medicine
  • Published in
    Nature Structural &Molecular…
    2009
  • DOI:10.1038/nsmb.1573

Precursor-product discrimination by La protein during tRNA metabolism

@inproceedings{Bayfield2009PrecursorproductDB,
  title={Precursor-product discrimination by La protein during tRNA metabolism},
  author={Mark A. Bayfield and Richard J Maraia},
  booktitle={Nature Structural &Molecular Biology},
  year={2009}
}
La proteins bind pre-tRNAs at their UUU-3′OH ends, facilitating their maturation. Although the mechanism by which La binds pre-tRNA 3′ trailers is known, the function of the RNA binding β-sheet surface of the RNA-recognition motif (RRM1) is unknown. How La dissociates from UUU-3′OH–containing trailers after 3′ processing is also unknown. Here we show that La preferentially binds pre-tRNAs over processed tRNAs or 3′ trailer products through coupled use of two sites: one on the La motif and… CONTINUE READING

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 23 CITATIONS

RNA Chaperone Activity of Human La Protein Is Mediated by Variant RNA Recognition Motif*

  • The Journal of biological chemistry
  • 2012
VIEW 10 EXCERPTS
CITES BACKGROUND, METHODS & RESULTS

An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursors.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2011
VIEW 9 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

An interdomain bridge influences RNA binding of the human La protein.

  • The Journal of biological chemistry
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 53 REFERENCES

regulation and role of La protein

French, S. L. et al. Visual analysis of the yeast 5S rRNA gen transcriptome
  • Mol. Cell. Biol. 28, 4576–4587
  • 2008

3¢-end recognition by the human La protein

S. Curry, Conte, M. R. A terminal affair
  • Trends Biochem. Sci. 31, 303–305
  • 2006