Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

@article{Koo1990PrecursorOA,
  title={Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.},
  author={Edward H. Koo and Sangram S. Sisodia and David R Archer and Lee J. Martin and Andreas Weidemann and Konrad Beyreuther and Peter M. Fischer and Colin L. Masters and Donald L. Price},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 4},
  pages={1561-5}
}
In the brains of aged humans and cases of Alzheimer disease, deposits of amyloid in senile plaques are located in proximity to nerve processes. The principal component of this extracellular amyloid is beta/A4, a peptide derived from a larger amyloid precursor protein (APP), which is actively expressed in brain and systemic organs. Mechanisms that result in the proteolysis of APP to form beta/A4, previously termed beta-amyloid protein, and the subsequent deposition of the peptide in brain are… CONTINUE READING

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