Precursor ion scanning and sequencing of arginine-ADP-ribosylated peptide by mass spectrometry.

@article{Osago2009PrecursorIS,
  title={Precursor ion scanning and sequencing of arginine-ADP-ribosylated peptide by mass spectrometry.},
  author={H. Osago and Kazuo Yamada and T. Shibata and K. Yoshino and N. Hara and M. Tsuchiya},
  journal={Analytical biochemistry},
  year={2009},
  volume={393 2},
  pages={
          248-54
        }
}
Arginine (Arg)-specific ADP-ribosylation is one of the posttranslational modifications of proteins and is thought to play an important role in reversibly regulating functions of the target proteins in eukaryotes. However, the physiological target protein has not been established. We examined the fragmentation pattern of both ADP-ribosyl-Arg (ADP-R-Arg) and Arg-ADP-ribosylated peptides by quadrupole tandem mass spectrometry and found a specific cleavage of ADP-R-Arg into N-(ADP-ribosyl… Expand
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