Precursor-directed biosynthesis of nonribosomal lipopeptides with modified glutamate residues.

@article{Powell2007PrecursordirectedBO,
  title={Precursor-directed biosynthesis of nonribosomal lipopeptides with modified glutamate residues.},
  author={Amanda Powell and Majid Al Nakeeb and Barrie Wilkinson and Jason Micklefield},
  journal={Chemical communications},
  year={2007},
  volume={26},
  pages={
          2683-5
        }
}
Precursor-directed biosynthesis of calcium dependent antibiotics (CDAs) with modified 3-trifluoromethyl and 3-ethyl glutamate residues was achieved by feeding synthetic glutamate analogues to a mutant strain of Streptomyces coelicolor impaired in the biosynthesis of the natural precursor (2S,3R)-3-methyl glutamic acid.