Precursor Medications as a Source of Methamphetamine and/or Amphetamine Positive Drug Testing Results
@article{Cody2002PrecursorMA, title={Precursor Medications as a Source of Methamphetamine and/or Amphetamine Positive Drug Testing Results}, author={John T. Cody}, journal={Journal of Occupational and Environmental Medicine}, year={2002}, volume={44}, pages={435-450} }
Medical Review Officer interpretation of laboratory results is an important component of drug testing programs. The clinical evaluation of laboratory results to assess the possibility of appropriate medical use of a drug is a task with many different facets, depending on the drug class considered. This intercession prevents the reporting of positive results unless it is apparent that drugs were used illicitly. In addition to the commonly encountered prescribed drugs that yield positive drug…
50 Citations
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The finding of each enantiomers by itself differentiates famprofazone use from the most commonly abused form of methamphetamine and all medicinal methamphetamine available in the U.S., which is either d-methamphetamine (prescription medication) or l-Meth methamphetamine (Vicks inhaler).
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- 2008
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To determine the methamphetamine and amphetamine excretion profile, samples were extracted, derivatized, and analyzed by gas chromatography-mass spectrometry (GC-MS), which revealed both enantiomers were present in a predictable pattern.
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References
SHOWING 1-10 OF 171 REFERENCES
Interpretation of methamphetamine and amphetamine enantiomer data.
- BiologyJournal of analytical toxicology
- 1993
Evaluation of experimentally derived and published data from urine samples containing l- and d,l-methamphetamine indicates that use of the enantiomeric distribution of amphetamine affords unambiguous interpretation.
Detection of amphetamine and methamphetamine following administration of benzphetamine.
- Biology, PsychologyJournal of analytical toxicology
- 1998
The metabolism of benzphetamine to desmethylbenzphetamine is a major pathway in the metabolism of the drug, and it is indicated that the origin of methamphetamine and amphetamine in urine samples is unknown.
Metabolic Precursors to Amphetamine and Methamphetamine.
- BiologyForensic science review
- 1993
Fourteen different metabolic precursors of amphetamine or methamphetamine are included in this review, and medical use, metabolism, analysis, and interpretation are described to afford sufficient information to evaluate the possible involvement of these drugs in positive amphetamineor methamphetamine results.
Metabolic Precursors to Amphetamine and Methamphetamine.
- Biology
- 1993
Fourteen different metabolic precursors of amphetamine or methamphetamine are included in this review, and medical use, metabolism, analysis, and interpretation are described to afford sufficient information to evaluate the possible involvement of these drugs in positive amphetamineor methamphetamine results.
ILLEGAL OR LEGITIMATE USE? PRECURSOR COMPOUNDS TO AMPHETAMINE AND METHAMPHETAMINE
- BiologyDrug metabolism reviews
- 2000
In this review, potential precursor compounds are described, including their medical use and major clinical effects and their metabolic profiles, as well as some clues which help to identify the sources.
Methamphetamine and amphetamine derived from the metabolism of selegiline.
- BiologyJournal of forensic sciences
- 1995
Routine methamphetamine testing identified a urine specimen with inconsistent screening and confirmation results that was later learned that the individual providing the specimen had been taking Selegiline, a monoamine oxidase inhibitor used for the treatment of Parkinson's disease.
Detection of amphetamine following administration of fenproporex.
- BiologyJournal of analytical toxicology
- 1996
Analysis of the metabolically produced amphetamine showed the presence of both enantiomers, which can be helpful in the differentiation of some illicit amphetamine use from the use of this precursor drug.
Metabolic production of amphetamine following multidose administration of clobenzorex.
- BiologyJournal of analytical toxicology
- 1999
This analysis revealed that the metabolite, (amphetamine) is present in much higher concentrations than the parent compound, clobenzorex, yet even at peak amphetamine concentrations, the parent was not always detected (limit of detection 1 ng/mL).
Enantiomeric composition of amphetamine and methamphetamine derived from the precursor compound famprofazone.
- BiologyForensic science international
- 1996
Amphetamine and fenproporex levels following multidose administration of fenproporex.
- BiologyJournal of analytical toxicology
- 1999
Analysis of the metabolically produced amphetamine showed the presence of both enantiomers, which can be helpful in the differentiation of some illicit amphetamine use from the use of this precursor drug.