Precoupling of Gi/G(o)-linked receptors and its allosteric regulation by monovalent cations.

Abstract

The ability of receptors (R) to activate G-proteins (G) is promoted by the binding of agonists, reflecting their induction of a receptor conformation which facilitates both the formation of a RG complex and guanine nucleotide exchange. Recent evidence from isolated membrane studies has indicated, however, that some receptors have the inherent ability to… (More)

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@article{Tian1993PrecouplingOG, title={Precoupling of Gi/G(o)-linked receptors and its allosteric regulation by monovalent cations.}, author={W N Tian and R C Deth}, journal={Life sciences}, year={1993}, volume={52 24}, pages={1899-907} }