Precore stop codon mutant in chronic hepatitis B virus infection in children: its relation to hepatitis B e seroconversion and maternal hepatitis B surface antigen.

@article{Chang1998PrecoreSC,
  title={Precore stop codon mutant in chronic hepatitis B virus infection in children: its relation to hepatitis B e seroconversion and maternal hepatitis B surface antigen.},
  author={Mei Hwei Chang and H Y Hsu and Yen-Hsuan Ni and Kei Sei Tsai and Ping I Lee and P. J. Chen and Yi-Hua Hsu and Ding Shinn Chen},
  journal={Journal of hepatology},
  year={1998},
  volume={28 6},
  pages={915-22}
}
BACKGROUND/AIMS The aims of this study were to investigate the significance of the precore stop codon mutant in the natural course of hepatitis B virus infection in children, and the influence of maternal transmission. METHODS Sequential sera from 80 hepatitis B virus carrier children both before and after e seroconversion during long-term follow-up were studied using the polymerase chain reaction-amplification created restriction site method. Direct sequencing of the precore region was… CONTINUE READING

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