Preconditioning with thrombin can be protective or worsen damage after endothelin-1-induced focal ischemia in rats.

@article{HenrichNoack2006PreconditioningWT,
  title={Preconditioning with thrombin can be protective or worsen damage after endothelin-1-induced focal ischemia in rats.},
  author={Petra Henrich-Noack and Frank Striggow and Georg Reiser and Klaus G. Reymann},
  journal={Journal of neuroscience research},
  year={2006},
  volume={83 3},
  pages={469-75}
}
The serine protease thrombin has shown direct neuroprotective and neurotoxic effects on brain tissue in cerebral ischemia. Previous data suggested that thrombin-induced protection in vivo can be achieved by preconditioning rather than by acute treatment. In the current work, we used a model of mild ischemia to investigate the effects of preischemic intracerebral thrombin injection on neural damage. By intracerebral injection of endothelin-1 in freely moving animals, we achieved middle cerebral… CONTINUE READING

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