Preconditioning with isoflurane produces dose-dependent neuroprotection via activation of adenosine triphosphate-regulated potassium channels after focal cerebral ischemia in rats.

@article{Xiong2003PreconditioningWI,
  title={Preconditioning with isoflurane produces dose-dependent neuroprotection via activation of adenosine triphosphate-regulated potassium channels after focal cerebral ischemia in rats.},
  author={Li-ze Xiong and Yu Zheng and Mingchun Wu and Lichao Hou and Zhenghua Zhu and Xijing Zhang and Zhi-hong Lu},
  journal={Anesthesia and analgesia},
  year={2003},
  volume={96 1},
  pages={
          233-7, table of contents
        }
}
UNLABELLED In this study, we determined whether repeated brief isoflurane (Iso) anesthesia induces ischemic tolerance to focal cerebral ischemia in a dose-response manner and whether the effect is dependent on adenosine triphosphate-regulated potassium channels. In Experiment 1, 40 rats were randomly assigned to 4 groups: control animals received 100% oxygen 1 h/d for 5 days, whereas the isoflurane (Iso)1, Iso2, and Iso3 groups received 0.75%, 1.5%, or 2.25% Iso in oxygen 1 h/d for 5 days. In… CONTINUE READING

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