Preconditioning with cortical spreading depression decreases intraischemic cerebral glutamate levels and down-regulates excitatory amino acid transporters EAAT1 and EAAT2 from rat cerebal cortex plasma membranes.

@article{Douen2000PreconditioningWC,
  title={Preconditioning with cortical spreading depression decreases intraischemic cerebral glutamate levels and down-regulates excitatory amino acid transporters EAAT1 and EAAT2 from rat cerebal cortex plasma membranes.},
  author={Andre G. Douen and Kazufumi Akiyama and MichaelJ. Hogan and Fang Wang and Li Dong and A. K. K. Chow and Antoine Hakim},
  journal={Journal of neurochemistry},
  year={2000},
  volume={75 2},
  pages={
          812-8
        }
}
We previously reported a 50% reduction in cortical infarct volume following transient focal cerebral ischemia in rats preconditioned 3 days earlier with cortical spreading depression (CSD). The mechanism of the protective effect of prior CSD remains unknown. Recent studies demonstrate reversal of excitatory amino acid transporters (EAATs) to be a principal cause for elevated extracellular glutamate levels during cerebral ischemia. The present study measured the effect of CSD preconditioning on… CONTINUE READING
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