Preconditioning with bright light evokes a protective response against light damage in the rat retina.

@article{Liu1998PreconditioningWB,
  title={Preconditioning with bright light evokes a protective response against light damage in the rat retina.},
  author={Chengxun Liu and Min Peng and Alan Malev Laties and Rizhen Wen},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 4},
  pages={
          1337-44
        }
}
Constant exposure to bright light induces photoreceptor degeneration and at the same time upregulates the expression of several neurotrophic factors in the retina. At issue is whether the induced neurotrophic factors protect photoreceptors. We used a preconditioning paradigm to show that animals preconditioned with bright light became resistant to subsequent light damage. The preconditioning consisted of a 12-48 hr preexposure, followed by a 48 hr "rest phase" of normal cyclic lighting. The… CONTINUE READING

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Exposure to constant light upregulates the expression of bFGF, CNTF, FGFR-1, and GFAP mRNAs in the rat retina

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