Preconditioning with 1,25-dihydroxyvitamin D3 protects against subsequent ischemia-reperfusion injury in the rat kidney.

@article{Kim2005PreconditioningW1,
  title={Preconditioning with 1,25-dihydroxyvitamin D3 protects against subsequent ischemia-reperfusion injury in the rat kidney.},
  author={Young Ok Kim and Can Li and Bo kyung Sun and Jung Sim Kim and Sun Woo Lim and Bun Soon Choi and Yong Soo Kim and Jin Oak Kim and Byung Kee Bang and Chul Woo Yang},
  journal={Nephron. Experimental nephrology},
  year={2005},
  volume={100 2},
  pages={
          e85-94
        }
}
BACKGROUND/AIM Induction of heat shock protein 70 (HSP70) is important in the tolerance of subsequent ischemia-reperfusion (I/R) injury. The aim of this study was to evaluate the effect of HSP70 induction by 1,25-dihydroxyvitamin D3 (VD3) on subsequent I/R injury in rats. METHODS HSP70 was induced in Sprague-Dawley rats by VD3 treatment for 7 days, and the effect of VD3 pretreatment on subsequent I/R injury was evaluated in terms of renal function, tubular necrosis score, tumor necrosis… CONTINUE READING

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