Preconditioning protects ischemic rabbit heart by protein kinase C activation.

  title={Preconditioning protects ischemic rabbit heart by protein kinase C activation.},
  author={Kirsti Ytrehus and Yongge Liu and James M. Downey},
  journal={The American journal of physiology},
  volume={266 3 Pt 2},
Myocardial protection in the rabbit induced by ischemic preconditioning is thought to be adenosine receptor linked, but the signaling pathway responsible for the protection has yet to be identified. This study tests whether protein kinase C could be involved. Either of two inhibitors of protein kinase C, staurosporine (50 micrograms/kg) or polymyxin B (24 mg/kg), were administered to rabbits subjected to 30 min regional myocardial ischemia followed by 180 min reperfusion. Half of the rabbits… CONTINUE READING
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