Preconditioning promotes survival and angiomyogenic potential of mesenchymal stem cells in the infarcted heart via NF-kappaB signaling.

@article{Afzal2010PreconditioningPS,
  title={Preconditioning promotes survival and angiomyogenic potential of mesenchymal stem cells in the infarcted heart via NF-kappaB signaling.},
  author={Muhammad R Afzal and Husnain K H Haider and Niagara Muhammad Idris and Shujia Jiang and Rafeeq P. H. Ahmed and Muhammad Ashraf},
  journal={Antioxidants & redox signaling},
  year={2010},
  volume={12 6},
  pages={693-702}
}
We proposed that pharmacological manipulation of mesenchymal stem cells (MSCs) with diazoxide enhanced their survival and regenerative potential via NFkappaB regulation. MSCs preconditioned ((PC)MSCs) with diazoxide and later subjected to oxidant stress with 100 micromol/L H(2)O(2) either immediately or after 24 h exhibited higher survival (p < 0.01 vs nonpreconditioned MSCs; (Non-PC)MSCs) with concomitantly increased phosphorylation of PI3K, Akt, GSK3beta (cytoplasmic), and NF-kappaB (p65… CONTINUE READING

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