Preconditioning of the ischaemic myocardium; involvement of the L-arginine nitric oxide pathway.

@article{Vgh1992PreconditioningOT,
  title={Preconditioning of the ischaemic myocardium; involvement of the L-arginine nitric oxide pathway.},
  author={{\'A}gnes V{\'e}gh and Laszlo Szekeres and James Roy Parratt},
  journal={British journal of pharmacology},
  year={1992},
  volume={107 3},
  pages={648-52}
}
1. Short periods of coronary artery occlusion protect the heart against the effects of a subsequent prolonged period of ischaemia. This phenomenon is known as preconditioning of the ischaemic myocardium. 2. In mongrel, chloralose-urethane anaesthetized open-chest dogs, within a restricted body weight range, two 5 min periods of occlusion of the anterior descending branch of the left coronary artery markedly reduced the severity of the early ischaemic arrhythmias resulting from a prolonged (25… CONTINUE READING

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