Preconditioning of adipose tissue-derived mesenchymal stem cells with deferoxamine increases the production of pro-angiogenic, neuroprotective and anti-inflammatory factors: Potential application in the treatment of diabetic neuropathy

@inproceedings{Oses2017PreconditioningOA,
  title={Preconditioning of adipose tissue-derived mesenchymal stem cells with deferoxamine increases the production of pro-angiogenic, neuroprotective and anti-inflammatory factors: Potential application in the treatment of diabetic neuropathy},
  author={Carolina Oses and Belen Olivares and Marcelo Ezquer and Cristian Acosta and Paul Bosch and Macarena Gonz{\'a}lez Donoso and Patricio L{\'e}niz and Fernando Ezquer},
  booktitle={PloS one},
  year={2017}
}
Diabetic neuropathy (DN) is one of the most frequent and troublesome complications of diabetes mellitus. Evidence from diabetic animal models and diabetic patients suggests that reduced availability of neuroprotective and pro-angiogenic factors in the nerves in combination with a chronic pro-inflammatory microenvironment and high level of oxidative stress, contribute to the pathogenesis of DN. Mesenchymal stem cells (MSCs) are of great interest as therapeutic agents for regenerative purposes… CONTINUE READING

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