Preconditioning of Microglia by α-Synuclein Strongly Affects the Response Induced by Toll-like Receptor (TLR) Stimulation

@inproceedings{Roodveldt2013PreconditioningOM,
  title={Preconditioning of Microglia by α-Synuclein Strongly Affects the Response Induced by Toll-like Receptor (TLR) Stimulation},
  author={Cintia Roodveldt and Adahir Labrador-Garrido and Elena G{\'o}nzalez-Rey and Christian Claude Lachaud and Tim T. Guilliams and Rafael Fern{\'a}ndez-Montesinos and Alicia Ben{\'i}tez-Rond{\'a}n and Gema Robledo and Abdelkrim Hmadcha and Mario Delgado and Christopher M. Dobson and David Patricio Viscarra del Pozo},
  booktitle={PloS one},
  year={2013}
}
In recent years, it has become accepted that α-synuclein (αSyn) has a key role in the microglia-mediated neuroinflammation, which accompanies the development of Parkinson's disease and other related disorders, such as Dementia with Lewy Bodies and Alzheimer's disease. Nevertheless, the cellular and molecular mechanisms underlying its pathological actions, especially in the sporadic forms of the diseases, are not completely understood. Intriguingly, several epidemiological and animal model… CONTINUE READING
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phagocytosis is enhanced by monomeric alpha - synuclein , not aggregated alpha - synuclein : implications for Parkinson ' s disease

  • R Shechter, M Schwartz
  • Microglial
  • 2013

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