Preconditioning mesenchymal stem cells with the mood stabilizers lithium and valproic acid enhances therapeutic efficacy in a mouse model of Huntington's disease.

@article{Linares2016PreconditioningMS,
  title={Preconditioning mesenchymal stem cells with the mood stabilizers lithium and valproic acid enhances therapeutic efficacy in a mouse model of Huntington's disease.},
  author={Gabriel R. Linares and Chi-Tso Chiu and Lisa Scheuing and Yan Leng and Hsiao-Mei Liao and Dragan Maric and D. M. Chuang},
  journal={Experimental neurology},
  year={2016},
  volume={281},
  pages={81-92}
}
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by CAG repeat expansions in the huntingtin gene. Although, stem cell-based therapy has emerged as a potential treatment for neurodegenerative diseases, limitations remain, including optimizing delivery to the brain and donor cell loss after transplantation. One strategy to boost cell survival and efficacy is to precondition cells before transplantation. Because the neuroprotective actions of the mood stabilizers lithium and… CONTINUE READING
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