Preconditioning limits myocardial infarct size in hypercholesterolemic rabbits.

  title={Preconditioning limits myocardial infarct size in hypercholesterolemic rabbits.},
  author={Dimitrios T h Kremastinos and Elias Bofilis and George K. Karavolias and Apostolos Papalois and Loukas Kaklamanis and Efstathios K. Iliodromitis},
  volume={150 1},
BACKGROUND Hypercholesterolemia predisposes to coronary artery disease and causes endothelial dysfunction; some reports suggest that endothelial derived substances are involved in ischemic preconditioning. OBJECTIVE Our aim was to examine the possibility that preconditioning maybe attenuated in a clinically relevant animal model of hypercholesterolemia with atherosclerosis. METHODS Male rabbits were fed with cholesterol enriched diet and then divided into two groups (A and B) without and… CONTINUE READING


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