Preconditioning-induced protection from oxidative injury is mediated by leukemia inhibitory factor receptor (LIFR) and its ligands in the retina.

@article{Chollangi2009PreconditioninginducedPF,
  title={Preconditioning-induced protection from oxidative injury is mediated by leukemia inhibitory factor receptor (LIFR) and its ligands in the retina.},
  author={Srinivas Chollangi and Jiangang Wang and Aaron Martin and John W. Quinn and John D Ash},
  journal={Neurobiology of disease},
  year={2009},
  volume={34 3},
  pages={535-44}
}
Preconditioning with moderate oxidative stress (e.g., moderate bright light or mild hypoxia) can induce changes in retinal tissue that protect photoreceptors from a subsequent dose of lethal oxidative stress. The mechanism underlying this induced protection is likely a general mechanism of endogenous protection which has been demonstrated in heart and brain using ischemia and reperfusion. While multiple factors like bFGF, CNTF, LIF and BDNF have been hypothesized to play a role in… CONTINUE READING
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