Preconditioning in the absence or presence of sustained ischemia modulates myocardial Cx43 protein levels and gap junction distribution.

@article{Daleau2001PreconditioningIT,
  title={Preconditioning in the absence or presence of sustained ischemia modulates myocardial Cx43 protein levels and gap junction distribution.},
  author={Pascal Daleau and S Boudriau and Magali Michaud and Christine Jolicoeur and John G Kingma},
  journal={Canadian journal of physiology and pharmacology},
  year={2001},
  volume={79 5},
  pages={371-8}
}
In the heart, brief repeated episodes of ischemia prior to a sustained occlusion (ischemic preconditioning; PC) significantly delay the onset of necrosis and arrhythmogenesis. Ischemia has been reported to influence gap junction organization and connexin43 (Cx43) content, but whether PC affects these structures is not known. We investigated the effect of PC (2 cycles of 5-min ischemia plus 10-min reperfusion) followed by prolonged reperfusion without concomitant regional coronary occlusion on… CONTINUE READING

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