Preconditioning decreases Bax expression, PMN accumulation and apoptosis in reperfused rat heart.

@article{Nakamura2000PreconditioningDB,
  title={Preconditioning decreases Bax expression, PMN accumulation and apoptosis in reperfused rat heart.},
  author={Motoomi Nakamura and Nan Ping Wang and Zhong Qiu Zhao and Josiah N. Wilcox and Vinod H. Thourani and Robert A. Guyton and Jakob Vinten-Johansen},
  journal={Cardiovascular research},
  year={2000},
  volume={45 3},
  pages={
          661-70
        }
}
OBJECTIVE Recent studies suggest that ischemic preconditioning (IPC) inhibits myocardial apoptosis after ischemia and reperfusion. This study tested the hypothesis that IPC reduces ischemia/reperfusion-induced myocardial apoptosis by inhibiting neutrophil (PMN) accumulation and altering expression of Bcl-2 and Bax proteins. METHODS Eighteen rats were subjected to 30 min of left coronary artery occlusion followed by 180 min of reperfusion with IPC (5 min ischemia and 10 min of reperfusion, n… CONTINUE READING
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