Preconditioning by sesquiterpene lactone enhances H2O2-induced Nrf2/ARE activation.

@article{Umemura2008PreconditioningBS,
  title={Preconditioning by sesquiterpene lactone enhances H2O2-induced Nrf2/ARE activation.},
  author={K. Umemura and T. Itoh and Nanako Hamada and Y. Fujita and Y. Akao and Y. Nozawa and N. Matsuura and M. Iinuma and Masafumi Ito},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={368 4},
  pages={
          948-54
        }
}
The Nrf2/ARE pathway plays a pivotal role in chemoprevention and neuroprotection. Here, we report that sesquiterpene lactones extracted from Calea urticifolia and feverfew increased enhancer activity of the ARE. ARE activation was dependent on the number of alpha,beta-unsaturated carbonyl groups each compound bears and calealactone A (CL-A) harboring 3 of those was the most potent ARE inducer. At subtoxic doses, CL-A induced expression of heme oxygenase-1 (HO-1) gene, one of ARE target genes… Expand
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