Preconceptional Folate Supplementation and the Risk of Spontaneous Preterm Birth: A Cohort Study

@article{Bukowski2009PreconceptionalFS,
  title={Preconceptional Folate Supplementation and the Risk of Spontaneous Preterm Birth: A Cohort Study},
  author={Radek K Bukowski and Fergal Desmond Malone and Flint T. Porter and David A. Nyberg and Christine H. Comstock and Gary D. V. Hankins and Keith A. Eddleman and Susan J. Gross and Lorraine Dugoff and Sabrina D. Craigo and I E Timor-Tritsch and Stephen R. Carr and Honor M. Wolfe and Mary E D'alton},
  journal={PLoS Medicine},
  year={2009},
  volume={6},
  pages={2379 - 2385}
}
BACKGROUND Low plasma folate concentrations in pregnancy are associated with preterm birth. Here we show an association between preconceptional folate supplementation and the risk of spontaneous preterm birth. METHODS AND FINDINGS In a cohort of 34,480 low-risk singleton pregnancies enrolled in a study of aneuploidy risk, preconceptional folate supplementation was prospectively recorded in the first trimester of pregnancy. Duration of pregnancy was estimated based on first trimester… CONTINUE READING
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