Preclinical toxicology study of liposome encapsulated doxorubicin (TLC D-99): comparison with doxorubicin and empty liposomes in mice and dogs.

@article{Kanter1993PreclinicalTS,
  title={Preclinical toxicology study of liposome encapsulated doxorubicin (TLC D-99): comparison with doxorubicin and empty liposomes in mice and dogs.},
  author={Peter M. Kanter and Gary A. Bullard and F G Pilkiewicz and Lawrence D. Mayer and Pieter R Cullis and Zlatko P. Pavelic},
  journal={In vivo},
  year={1993},
  volume={7 1},
  pages={85-95}
}
A preclinical toxicology study of intravenously administered liposome encapsulated doxorubicin (TLC D-99), free doxorubicin and empty liposomes was carried out in mice and dogs by single and multiple (daily for 5 days) dose schedules. Single dose intravenous injection studies in mice showed the encapsulated form of doxorubicin to be less toxic (LD50 of 32… CONTINUE READING