Preclinical toxicological studies of carbidopa and combinations of carbidopa and levodopa.

@article{Zwickey1974PreclinicalTS,
  title={Preclinical toxicological studies of carbidopa and combinations of carbidopa and levodopa.},
  author={R E Zwickey and Harold M. Peck and Walter J. Bagdon and Delwin L. Bokelman and Walter R. Brown and Mark Hite and Richard D. Jensen and Paul A. Mattis and B. Mendlowski and Curt C. Porter},
  journal={Toxicology and applied pharmacology},
  year={1974},
  volume={29 2},
  pages={
          181-95
        }
}
6 Citations

Pharmacology and toxicology of diflunisal.

Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity and produced focal oedema, haemorrhage and small ulcers in one or both species, while aspirin produced similar gastric and renal toxicity in rats and dogs.

Levodopa and Decarboxylase Inhibitors: A Review of their Clinical Pharmacology and Use in the Treatment of Parkinsonism

It is possible to treat more Parkinsonian patients effectively with the combinations than withlevodopa alone, especially those in whom optimum dosage of levodopa cannot be reached because of dose-limiting side-effects.

Nigrostriatal Dopaminergic Neurons Remain Undamaged in Rats Given High Doses of l‐DOPA and Carbidopa Chronically

It seems unlikely that a model of Parkinson's disease, suitable for exploring the etiological importance of glutathione deficiency, can be produced in rats merely by administering the largest tolerable doses of l‐DOPA.

Preliminary evidence of increased striatal dopamine in a nonhuman primate model of maternal immune activation

Nonhuman primates born to MIA-treated dams exhibited increased striatal dopamine in late adolescence—a hallmark molecular biomarker of schizophrenia, which validate the MIA model in a species more closely related to humans and open up new avenues for understanding the neurodevelopmental biology of schizophrenia.

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Radioactivity in the rat showed that after 1 hr radioactivity was concentrated relative to the plasma in the kidney, lungs, small intestine, and liver, and Unchanged carbidopa was excreted in the urine of man, monkey, dog, and rat.

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