Preclinical toxicological studies of carbidopa and combinations of carbidopa and levodopa.

  title={Preclinical toxicological studies of carbidopa and combinations of carbidopa and levodopa.},
  author={R E Zwickey and Harold M. Peck and Walter J. Bagdon and Delwin L. Bokelman and Walter R. Brown and Mark Hite and Richard D. Jensen and Paul A. Mattis and B. Mendlowski and Curt C. Porter},
  journal={Toxicology and applied pharmacology},
  volume={29 2},
6 Citations

Levodopa and Decarboxylase Inhibitors: A Review of their Clinical Pharmacology and Use in the Treatment of Parkinsonism

It is possible to treat more Parkinsonian patients effectively with the combinations than withlevodopa alone, especially those in whom optimum dosage of levodopa cannot be reached because of dose-limiting side-effects.

Preliminary evidence of increased striatal dopamine in a nonhuman primate model of maternal immune activation

Nonhuman primates born to MIA-treated dams exhibited increased striatal dopamine in late adolescence—a hallmark molecular biomarker of schizophrenia, which validate the MIA model in a species more closely related to humans and open up new avenues for understanding the neurodevelopmental biology of schizophrenia.

Nigrostriatal Dopaminergic Neurons Remain Undamaged in Rats Given High Doses of l‐DOPA and Carbidopa Chronically

It seems unlikely that a model of Parkinson's disease, suitable for exploring the etiological importance of glutathione deficiency, can be produced in rats merely by administering the largest tolerable doses of l‐DOPA.

Pharmacology and toxicology of diflunisal.

Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity and produced focal oedema, haemorrhage and small ulcers in one or both species, while aspirin produced similar gastric and renal toxicity in rats and dogs.




In the hydrazine-treated group of monkeys, serum glutamic oxaloacetic transaminase and bilirubin rose with doses of 20 mg/kg, with more than a twentyfold increase of SGOT in two animals.

Chronic toxicity of carboethoxyphthalazinohydrazine and its influence on the excretion of 5-hydroxyindoleacetic acid and the activity of 5-htp-decarboxylase in white rats.

  • M. Chruściel
  • Medicine, Biology
    British journal of pharmacology and chemotherapy
  • 1968
Routine laboratory examination of the urine and its sediment was performed and the activities of DOPA-and 5-HTP-decarboxylase in fresh homogenates of rat liver with the addition of CEPH, or 1: 4-dihydrazinophthalazine (Nepresol) compared with control activities.

Induction of pulmonary tumors in mice with isonicotinic acid hydrazid.

The purpose of the present work was to determine in more precise manner the minimum dose of INH and other similar compounds required to induce pulmonary tumors.

Neurologic, neuropathologic, and neurochemical effects of prolonged administration of phenylisopropylhydrazine (JB 516), phenylisobutylhydrazine (JB 835), and other monoamine oxidase inhibitors.

Dogs showed markedly elevated serotonin and unchanged norepinephrine levels in brain stem and spinal cord after prolonged administration of all potent monoamine oxidase inhibitors, demonstrating the danger of delayed toxicity with chronic administration of some drugs.

Pulmonary Tumours in Mice induced by Oral Isoniazid and its Metabolites

Juha\s̀z et al.1 induced solitary or multiple pulmonary adenomas in 7 of 45 albino mice which received intraperitoneal injections of isoniazid in water for three months and survived for

Potentiation and inhbition of some central actions of L(-)-dopa by decarboxylase inhibitors.

It is concluded that decarboxylase inhibitors can either inhibit or potentiate the central actions of i.-dopa depending upon whether they reach the brain sites where L-dopa acts.

Experimental production of Heinz bodies in the pig.