Preclinical toxicity evaluation of AAV for pain: evidence from human AAV studies and from the pharmacology of analgesic drugs

@inproceedings{Pleticha2014PreclinicalTE,
  title={Preclinical toxicity evaluation of AAV for pain: evidence from human AAV studies and from the pharmacology of analgesic drugs},
  author={Josef Pleticha and Lukas F Heilmann and Christopher H. Evans and Aravind Asokan and Richard Jude Samulski and Andreas S. Beutler},
  booktitle={Molecular pain},
  year={2014}
}
Gene therapy with adeno-associated virus (AAV) has advanced in the last few years from promising results in animal models to >100 clinical trials (reported or under way). While vector availability was a substantial hurdle a decade ago, innovative new production methods now routinely match the scale of AAV doses required for clinical testing. These advances… CONTINUE READING